Frederick County Biotech Community

Everything Biotech in Frederick County, Maryland

Archive for January, 2008

The Great Maryland Smoke Out

Posted by Jim H on January 31, 2008

I don’t like to “overblog” myself, but I have been thinking about this post all morning and don’t really have much lab work to do this morning.

So today is the last day to smoke in bars and restaurants in Maryland.  My oh my, how times have changed.

When I was at Greece Athena High school from Sept. 1975 until June 1980, our student “Smoking Lounge” was the hallway between the girls locker room and the swimming pool.  During nicer weather, the “heads” could also smoke outside, but generally the doors were closed.  This prevented most kids from smoking in the bathrooms and stairways.  Most.  It also faintly masked the odor of the non-tobacco smoking that was a regular activity.  Faintly masked.  No one was really fooled.  I didn’t smoke then, but every single day I was in High School, someone smoked on the bus.

I started smoking in 1980, at 18,  while a freshman in college at Wittenberg University.  Just about everybody in my dorm were smokers.  There were no restrictions for smoking of any sort in the dorms.  You weren’t allowed to smoke in class rooms during class.  I remember Dr. Curry walking into Organic Chemistry every day with a lit cigarette in his mouth, snuffing it out as he reached the lectern (not a podium, one of the more valuable lesson I learned at Wittenberg).  He would turn to the blackboard and commence class by reciting the page number from Morrison & Boyd  he was starting on, scrawl out equations on the board for 45 minutes, then light a new cigarette and walk out.

My daughter’s at Towson now.  They have a vote out to band smoking on the entire campus! That’s nuts.

Everything started to change in the mid-80’s with revelations of Betty Fords problems and Nancy Reagan’s “Just Say NO” campaign. After college and a couple years in sales at Home Show USA and Xerox, a crap job as a QC Tech and Chemical Mixer at KleenBrite, I got a job at the University of Rochester School of Medicine & Dentistry as a Lab Tech.  Dr Young didn’t want smoking in the lab, so we smoked liberally in the adjoining Lunchroom and rest rooms.  Some of the other Grad students and PI’s were smokers, too, as was the Department Head.  Lab coats and safety glasses were available, but rarely used. I remember doing one experiment where I was infecting fresh human foreskin with P32, 90 mCi of P32.  In a Laminar flow hood (since BSC’s were not readily used).  Blowing in my face.  I wore a ring badge for that one, but there was no indication of a dose when we sent it out for development.

One time I was walking down the hallway and heard a Geiger counter squealing, saturated.  When I stuck my head in the lab, there was Dr. X (I don’t remember his name, but he was a Md/PhD and PI), with a cup of coffee on one side, lit cigarette in an ash tray on the other side and in the middle was his reaction.  He was labeling thyroid tissue with 3 Ci of I 125.  Yes, 3 curries.  He was matter-of-factly like, “Yeah, it’s short 1/2 life, low energy.  You get a bigger dose doing a thyroid scan”.

So I moved to Maryland in 1988.  We smoked in the lab, drank in the lab, ate in the lab.  Lab coats were optional.  Then around 1990, smoking in the labs was prohibited, so we moved our ash trays out into the hallway.  The a couple years later, smoking in the hallways was banned, so we had to smoke in the lunchroom.  Then a year or so later, smoking in “common” areas was banned.  Fortunately, you were still allowed to smoke in private offices.  I remember around ‘92 being lectured by the Director of EHS because I protested to getting rabies immunizations after being bitten by a squirrel that had made it into the lab through a exterior vent pipe.  As he drew on his pipe, he made it clear that getting the series of rabies shots would be a condition of my continued employment. Ouch.   At the time, our Department Head was also a smoker and she declared that anyone, at any time, was invited to her office to smoke.

That said, I haven’t smoked inside my own house since 1989 when our first daughter was born.  I guess from tomorrow on, I’ll be blowing smoke into the throngs of anxious patrons as they make their way into their favorite drinking establishment.

Posted in Rants | 1 Comment »

Leaving the Nest

Posted by Jim H on January 31, 2008

There is a nice article in the FNP today about how incubator companies find it hard to afford Lab space once they move out of the incubator system. I don’t disagree, but the time comes when we all have to leave the nest. Not leaving the nest means you were not very successful. The article cites data provided by a study commissioned by TEDCO, as well as some facts supplied by Mike Dailey in a briefing to County Commissioners in November.

Here is the link to the Executive summary of TEDCO’s study on Maryland incubators’ economic impact is from the TEDCO website: www.marylandtedco.org

Key Data Points Resulting From the Impact Analysis:
Incubator Firms in 2006:

• Employed 14,044 employees in the state (5,374 direct employees and 8,670 indirect employees)
• These jobs contributed $845 million in annual salary and benefits to Maryland households
• Gross state product contributions totaled $1.2 billion
• Increased state output by $2.7 billion per year
• Contributed $104 million in state and local taxes.
Incubators in Maryland:
• 18 technology incubators in operation comprising 453,061 square feet
• 4 proposed technology incubators

Future Implications:

• Maryland has a strong high-tech industry, with over 15,000 establishments employing almost 200,000 in 2006.
• The average annual pay for high-tech jobs is $75,000, more than 60% higher than the statewide average annual wage of $46,000.
• The high-tech industry in Maryland overall has a location quotient of 1.54, indicating that employment in high-tech industries in Maryland is more highly concentrated than in other states in the nation. (An LQ between 0.75 and 1.25 is interpreted to mean that employment is similar to the national average. An LQ above 1.25 indicates concentration).
• The three most concentrated industries are management, scientific, and technical consulting services (LQ = 3.01); computer systems design and related services (LQ = 2.33); and communications equipment manufacturing (LQ =2.06).
• Academic R&D totaled $2.36 billion in 2005. This is the fourth highest in the nation and surpasses North Carolina, Massachusetts and Virginia. (that was mis-quoted in the FNP article)
• There are over 40 research centers in Maryland, including a significant presence of federal labs and prominent university institutes.
• Taken together, these facts provide the state with a strong foundation for additional technology incubator growth.

AT A GLANCE Frederick Innovative Technology Center’s impact to date

> Frederick County Commissioners invested $275,000

> Maryland donated $8.27 for each county dollar spent:

> TEDCO grants totaled $1,625,000

> Maryland DBED grants totaled $650,000

> Each FITCI job worth $7,404 in state and local taxes

> 106 jobs at FITCI worth $784,962 in state and local taxes

> FITCI tenants and graduates received more than $6.5 million in outside investment and more than $6.8 million in government grants

Source: Michael Dailey, executive director, FITCI, briefing to county commissioners, Nov. 20, 2007 (as reported in the Frederick News-Post 1/31/200 8)

I have interviewed Mike already and am awaiting his return of my Blogterview questions.  Hopefully, we’ll have that together soon.

Posted in Funding Available, Government Funded research, Jobs, News, Public/Private Companies | No Comments »

Building Bridges to Baltimore

Posted by Jim H on January 30, 2008

Last night I attended a dinner meeting in Baltimore, sponsored by the Greater Baltimore Tech Council called Face2Face. I have an ambitious goal of building bridges with the Biotech communities in the “Greater Baltimore” region and in Frederick.  I have alway found it ironic that there is a beautiful, wide open expanse of interstate highway linking the two Cities.  I can testify that the 40 mile commute to 695 can be readily accomplished in 30 minutes or less 99% of the time on Mon-Fri between 6 AM and 9 AM.  Not quite the same heading to the South East to Montgomery County and No Va.

So I am trying to keep the links I had established while spending the past 3 years  working in the Greater Baltimore Biotech scene, notably with the UMBC Tech Center in Catonsville.  I invited everyone from the GBTC to our BioBeers II festivities, but thus far no takers.  I have been receiving a steady stream of RSVP’s for BioBeers II.  I think we’ll at least hit 3X the inaugural events attendance, so come early!

Posted in Business, Events, Public/Private Companies | No Comments »

Homeland Security lab at Fort Detrick 60 percent complete

Posted by Jim H on January 28, 2008

There was a good article published in yesterday’s FNP about progress at Ft Detrick’s NIBC project. It was actually a merger between on posted the day before about the MD Biotech Investment Tax Credit: worth the Effort written by Jason Balog of Miles & Stockbridge. I have something to say about both.

With regard to the Tax Credit, let me relay my experience from attempting to obtain this credit last year. As the writer points out

“Although Maryland has some of the best programs in the country to assist start-up companies, most early stage companies are funded through the investment of the founders, their friends and families, and private individual investors known as “angels.” The Biotechnology Tax Credit was passed with the specific intention of encouraging this type of investment and in turn encouraging the growth of an industry.”

My application, despite numerous phone calls and two separate trips to Inner Harbor/Downtown Baltimore to hand deliver items that were not even specified as being necessary nor obvious in the application process, was reject on the basis that my company was not an “ongoing concern”. I think that was legalese for saying I was not really up and running and had no revenue on the books at this point in time, although i was paying rent at FITCI and making products and providing services. I thought that maybe I could catch a break and recover a bit of the $80-100,000 of my money (my family’s money) I was going to be investing to start my business. Not an ongoing concern.

You know what’s really funny, my partner at Advanced Product Enterprises, despite being in operation for 2 years at the time and generating a good amount of revenue, got the same rejection letter.

So in our case, the attempt to get the tax credit I wasted about $100 in fees associated with the application and lost at least 40 hours of productivity filling out the forms and delivering the goods. Clearly, not worth the effort. I wonder who got all of the money? I’ll have to look into that.

In the other part of the article, I attended the AFCEA luncheon on Jan 15th, featuring Michael Jewett, Chief, Integrated Planning Office and Program Manager, National Interagency Biodefense Campus (NIBC) at Ft. Detrick. He gave an excellent overview of the program, the building etc. He even showed an interactive Quicktime movie that allowed you to take a virtual tour of the BSL4 facilities. I believe that this should be available somewhere through freedom of information act, but I was not able to find it. I was able to find this overview, which is very similar to a presentation at AFCEA a couple months ago.

Just a reminder about AFCEA Frederick, if you are not familiar. The Frederick Chapter is based on getting more information out about what kinds of programs and resources are available through the Federal Government Agencies at Ft Detrick and it’s based primarily around the Biological nature of the businesses. There is a lunch Seminar on the third Tuesday of every month, and so far the seminars have been interesting and very informative. That food isn’t bad either, but they could use some work on their web site. I think in the future they are going to make all of the presentations available on-line.

Posted in Funding Available, Government Funded research, Rants | No Comments »

Moore Wealth

Posted by Jim H on January 28, 2008

As I said a couple weeks ago, I want to start being a bit less dependent on the local news feeds and start to try to generate some of my own newsworthy posts. A few weeks ago I sent a requests to complete a “Blogterview” questionarie. I actually have one that has been returned (last week actually, but I was lazy and haven’t followed-up).

I was introduced to Shabri shortly after moving into the incubator program here at FITCI. It seems that many entrepreneurs need financial advice and Shabri & company is almost like our surrogate investment advisory committe.

So I posed a few straight forward questions:

Fredcobio: What is the single most important thing a person can do with their money, aside from spending it?

Moore Wealth: Investing it. But of course, I’m going to say that!

Fredcobio: If a person wants to start their own business, what (free) advice would you give them?

Moore Wealth: Take the time to write a business plan.

Fredcobio: What is the biggest mistake people make when they start a business?

Moore Wealth: Not writing a business plan. It doesn’t have to be complicated. A quote from the movie Pirates of the Caribbean sums it up nicely “they’re really just guidelines you know”.

Fredcobio: If you were 40 years old (with a spouse and two Middle school aged children) and got laid off today and had $100,000 in your 401K plan, what would you do with it?

Moore Wealth: Roll it over into an IRA that you control. Just like you would never leave money in a bank account when you move from one city to another, never leave money in a company that you no longer work for. Then find a job!

Moore Wealth took advantage of my offer for Free Advertising a while back.  There may be a couple more added to the list and I have been approached by some people actually offering to pay to sponsor the blog!  I would like to find someone to sponsor BioBeers, but we can wait for the third or fourth one for that.

Posted in Blogterviews, Business, Funding Available | No Comments »

Science Blogs

Posted by Jim H on January 27, 2008

I do a lot of surfing, in my sare time, looking for stuff to write about, commenting on some of my favorite blogs and just reading other blogs for fun. I have “blogrolled” some of the blogs I read regularly in the column on the left. I will be addin gto it in the future.

If you’re a rookie, then the ScienceBlogs™ is a good place to start. This weekend I have been going through the list published on A Blog Around the Clock for the winners of the 2007

The Lab Fridge

Category: In the Lab
Posted on: May 10, 2007 10:00 AM, by RPM

Nothing captures life in the academic sciences quite like Piled Higher and Deeper. In yesterday’s comic, Jorge Cham shows us the disgusting innards of the lab/office fridge. Now, Jorge is a physicist engineer, so his fridge is the one where you’re supposed to store your food and drinks. When a biologist thinks of a lab fridge, he pictures something quite different. With that in mind, here’s my rendition of “The Lab Fridge”:

lab_fridge.gif

Aside from the empty bottles that some lazy, inconsiderate lab mate (most likely me) failed to refill, what’s missing from the fridge?

Here’s the whole list, for your reading pleasure:

The Poem:

Digital Cuttlefish

Much Ado About…The Brain?

The Comic:

Evolgen

The Lab Fridge

Essays:

10000 Birds

In Memory of Martha

Star Stryder

You are the Center of the Universe (and so am I, and so is Gursplex on Alpha Eck)

The Panda’s Thumb

Stuck on you, biological Velcro and the evolution of adaptive immunity and Behe vs Sea Squirts, fused into a single article.

Bad Astronomy

Happy New Year Arbitrary Orbital Marker!

Aetiology

Would you give your baby someone else’s breast milk?

Anterior Commissure

Why we bond - Individual recognition, evolution, and brain size

Retrospectacle: A Neuroscience Blog

How Much LSD Does It Take to Kill an Elephant

Archy

Visiting the Wenas mammoth and Looking for drowned mammoths fused into a single essay.

Backreaction

Science And Democracy III

The Questionable Authority

Adam, Eve, and why they never got married

Bit-player

Measure twice, average once

Bootstrap Analysis

Shrew party

Cocktail Party Physics

Genie in a Bottle

Evolving Thoughts

Ancestors

Coffee Talk

What is the meaning of (grad student) life?

A Blog Around The Clock

The Scientific Paper: past, present and probable future

Aardvarchaeology

Your Folks, My Folks in Prehistory

Creek Running North

Breathing in, breathing out

Thoughts from Kansas

Neither means, motive nor opportunity: a guide to dysteleology

Deanne Taylor’s blog

Faculty diversity in science

Deep-Sea News

Our Ocean Future: The Glass Half Empty and Our Ocean Future: The Glass Half Full fused into a single article.

Depth-First

SMILES and Aromaticity: Broken?

Duas Quartunciae

The Evolution of Wings

Effect Measure

Tamiflu resistance: digging beneath the headlines

The End Of The Pier Show

No Girrafes On Unicycles Beyond This Point

The Loom

Build Me A Tapeworm

The Pump Handle

Popcorn Lung Coming to Your Kitchen? The FDA Doesn’t Want to Know

Denialism blog

The Road to Sildenafil - A history of artifical erections

The Other 95%

Anemones Raise a Tentacle in Support of Evolution

Highly Allochthonous

Testability in Earth Science

Invasive Species Weblog

Square Pegs

Laelaps

Homo sapiens: What We Think About Who We Are (Redux)

Life of a Lab Rat

Riding with the King (also found here)

Living the Scientific Life

Schemochromes: The Physics of Structural Plumage Colors

The Primate Diaries

The Sacrifice of Admetus

Afarensis

The First Fossil Hunters: Paleontology in Greek and Roman Times

All of My Faults Are Stress Related

The Sound of Mylonites

Microecos

In the eyes of the Aye-ayes

Mind the Gap

In which I leap into the Void, In which I lift my finger from the ‘pause’ button, In which I contemplate the road taken, not taken, then re-taken and In which I rejoice in muscle memory fused into a single essay.

Omni Brain

How moving your eyes in a specific way can help you solve a problem

Minor Revisions

Indefensible

Neurologica

Sloppy Thinking about Homeopathy from The Guardian

Neurophilosophy

An illustrated history of trepanation

Notes from Ukraine

The Chernobyl liquidators: incredible men with incredible stories (Part 1), (Part 2), (Part 3) and Musings about the liquidators fused into a single article.

Pharyngula

Segmentation genes evolved undesigned

Pondering Pikaia

Moving Mountains

Quintessence of Dust

They selected teosinte…and got corn. Excellent!

Adventures in Ethics and Science

Getting ethics to catch on with scientists

Schneier on Security

Cyberwar

Shtetl-Optimized

Shor, I’ll Do It

Stranger Fruit

Pithecophobes of the World, Unite! Part I, Part II, Part III and Part IV all four fused into a single article.

Posted in Awards and recognition, General, Rants | No Comments »

Next BioBeer: Monday Feb. 4th

Posted by Jim H on January 25, 2008

It is time for BioBeer again. It looks like we’re going to do it on Monday, Feb 4th from 5 until 7 PM. I will send an e-mail to everyone on the list, so if you don’t get an e-mail and would like to join us, just leave a comment or fire me an e-mail.

Been busy as ever this week and haven’t had a chance to post anything, not that there hasn’t been a lot of news like this and this and this. That InvenioIP search engine is neat. You should check it out.

I am working on a couple posts that are requiring actual research. More to come, I promise.

By the the way, the Venue will be Barley & Hops again this time. I have been in contact with people at Flying Dog Brewery. As soon as I can get 20 or 30 people, we can have a private tour, with 16 beers on tap. And I have been told by friends at PerkinElmer that they will “sponsor” the event if we go. We can discuss this at B&H Monday, Feb 4th.

Be there or be square!

Posted in General, News, Rants | No Comments »

Congrats to Neuronascent on Landing DBED Funding

Posted by Jim H on January 16, 2008

A quick shout out to our friends at Neuronascent for landing $50,000 in DBED funding, according to an article today in the Baltimore Business Journal

I have been working with them on a number of projects using my amniotic stem cells.  Using their Cellomics ArrayScan machine, they can probe live cultures for hundreds of different markers and take some pretty nice pictures, too.

And I know  this article says that they are a Carrol County company, but their lab in in Frederick County, so they deserve a post here.

Posted in Awards and recognition, Business, Funding Available, Government Funded research, News, Public/Private Companies | No Comments »

Invitrogen Buys CellzDirect for $57 MM

Posted by Jim H on January 16, 2008

Last week, news broke that Invitrogen had acquired CellzDirect for $57 Million.

I was intrigued because in my last position at Celsis/In Vitro Technologies (IVT) , CellzDirect was our biggest competitor, I worked 14 years for LTI (which became Invitrogen) and Invitrogen remains one of the largest, if not the largest, biotech employer in the County.

IVT makes primary human hepatocytes.   We sold them to the largest drug companies around the globe for screening drug compound candidates for toxicity.  Although CellzDirect was our #1 competitor, a close #2 competitor was Cambrex/Lonza.

Even though CellzDirect is in North Carolina, I wonder what impact having a major player like Invitrogen enter the ring is going to have on both of these companies? Time will tell.

Posted in Business, News, Public/Private Companies, Rants | 1 Comment »

Banks, Biotechs and Buyouts

Posted by Jim H on January 14, 2008

I must’ve missed posting this nice article in the 12/27 edition of The Gazette. This is a nice summary of some of the things I have been talking about, and some other newsworthy stories to boot.

I have a busy week ahead, but I will be organizing the next BioBeers event soon.  Based on feedback, it seems that most people don’t visit the blog enough (I am getting only about 80 hits per day on weekdays and fewer on weekends) and would prefer to be invited by e-mail.

Everyone interested should check out the BioBeers Midwest web site, if you haven’t found it through the comments section, and also the Colorado Life Science Deal Flow site.  If we can move to this level of the blogosphere, I will be happy.

I also ran into a number of new blogroll sites through My Biotech Life I need to add.  Some really neat stuff going on that I will try to link for all of those not savy enough to surf to themselves.

Posted in Business, General, News | 1 Comment »