Genetic Characterization of Feline Leukemia Virus from Florida Panthers
Posted by Jim H on February 2, 2008
I ran across an interesting bit of research this morning while surfing. An article in the CDC Publication “Emerging Infectious Diseases”, authored by Meredith A. Brown, from NCI and Stephen J. O’Brien, SAIC-Frederick et al.
The suggested citation: Brown MA, Cunningham MW, Roca AL, Troyer JL, Johnson WE, O’Brien SJ. Genetic characterization of feline leukemia virus from Florida panthers. Emerg Infect Dis [serial on the Internet]. 2008 Feb [date cited]. Available from http://www.cdc.gov/EID/content/14/2/252.htm
Being in industry for the past 20 some odd years, I am not real hip on current publications and don’t even subscribe to PubMed. I get a lot out of the abstracts and turn to my more research-minded partners if I need to pull up a publication.
Here’s the abstract
From 2002 through 2005, an outbreak of feline leukemia virus (FeLV) occurred in Florida panthers (Puma concolor coryi). Clinical signs included lymphadenopathy, anemia, septicemia, and weight loss; 5 panthers died. Not associated with FeLV outcome were the genetic heritage of the panthers (pure Florida vs. Texas/Florida crosses) and co-infection with feline immunodeficiency virus. Genetic analysis of panther FeLV, designated FeLV-Pco, determined that the outbreak likely came from 1 cross-species transmission from a domestic cat. The FeLV-Pco virus was closely related to the domestic cat exogenous FeLV-A subgroup in lacking recombinant segments derived from endogenous FeLV. FeLV-Pco sequences were most similar to the well-characterized FeLV-945 strain, which is highly virulent and strongly pathogenic in domestic cats because of unique long terminal repeat and envelope sequences. These unique features may also account for the severity of the outbreak after cross-species transmission to the panther.
Does anyone know if there is a central site for Publications coming out of NCI, NIAD, SAIC or any of the other Agencies at Ft Detrick? Drop me a line if you do. This is the kind of research I would like to give more publicity to in my little space on the web.