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Armed Forces Institute of Regenerative Medicine coming to Ft Detrick

Posted by Jim H on April 27, 2008

I ran across an article in Medical News Today from 18 Feb:

Disfigured Wounded US Soldiers To Get New Skin, Ears And Fingers

Article Date: 18 Apr 2008 - 9:00 PDT

The US Department of Defense has announced the launch of a five year collaborative program to make use of cutting edge medical technology to treat service members who are badly disfigured from injuries received while serving in wars.

Giving an example of the type of innovative treatment the new initiative would be developing, Lt Gen Eric Schoomaker, who is Surgeon General of the US Army told a press conference held at the Pentagon yesterday, Thursday 17th April, about one case of a badly burned Marine who was going to receive a new ear grown from his own stem cells.

Using the patient’s own stem cells to regenerate replacement skin, tissue and other body parts is an area currently being explored by the new Armed Forces Institute of Regenerative Medicine (AFIRM) said Schoomaker.

AFIRM will come under the US Army’s leading medical research, development and acquisitions agency for related supplies, the US Army Medical Research and Material Command at Fort Detrick in Frederick, Maryland, which ultimately reports to Schoomaker in his capacity as Army Surgeon General.

I’m not clear from this article exactly how much of the research will occur at the Fort, but the possibilities are exciting to me, especially since I am working in the field. I knew that there was a bit of this research going on through DARPA funding, but I am glad that “RegMed 2.0″ has made it to the mainstream and Frederick is, once again, leading the pack.

For the initial five year period, AFIRM will be funded by an overall budget of around 250 million dollars, 80 of which will come from the Department of Defense, and the rest from organizations like the National Institutes of Health, the Department of Veterans Affairs, and matching funds from other public and private organizations.

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ChromoTrax Funding

Posted by Jim H on April 22, 2008

Some more good news today coming out of the “Incubator“.  According to the Baltimore Business Journal, Frederick’s own ChromoTrax was awarded a $50K grant from TEDCO for a collaboration with UMB for the “diagnosis and treatment of people with genetic-based diseases”.

I wonder if this means and end to androgenic alopecia?

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Seminar Announcement

Posted by Jim H on April 22, 2008

Every once in a while, I can be bribed enticed to post something happening outside Frederick County. Even though I had promised to do this last week, it is still not too late to let you know that Horiba and Microfluidics are cosponsoring a seminar in the Rockville, Maryland on April 24th. The Seminar will cover Particle Characterization and Bioprocessing. The review of the core Microfluidics technology will include new drug delivery applications.

More details from the Website:

Seminars

Particle Characterization and Processing Seminar and Workshop - CA

Thursday, April 24, 2008, 8:30 AM - 3:30 PM

The Legacy Hotel and Meeting Center

1775 Rockville Pike
Rockville, MD
310-881-2300

The Speakers:

Microfluidizer High-Shear Fluid Processing: Core Technology and BioPharmaceutical Applications

by Mimi Panagiotou, Ph.D., Microfluidics

High Level Expression Through Pichia Pastoris Fermentation

by Ben Woodard, University of Maryland

Process Development of a Novel Malaria Vaccine Candidate

by Richard Shimp, National Institute of Health, NIAID

Size Specifications in the Pharmaceutical Industry

by Mark Bumiller, HORIBA Instruments

Particle Size Method Development and Validation Support of NanoCrystal Colloidal Dispersion Formulation Characterization.

by Joost Straster, Elan Pharmaceuticals

Particle Characterization Applications in the Pharmacetuical Industry

by Mark Bumiller, HORIBA Instruments

There is no fee for this seminar, but reservations are required. Call 1-800-370-5452 x 234 or email Christian Beer to secure your reservation.

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More Pix and News to Report

Posted by Jim H on April 21, 2008

I am being pestered to place more pictures of BioBeers III on the web site. Thus far, only 7 people have figured out that by clicking the photo below, you would be exposed to a whole gamut of BioBeers II photos. So, here are a couple for those not capable of advancing their IT degrees…




I’ll try to post a couple other stories later.

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BioBeers III

Posted by Jim H on April 16, 2008


View Larger Map

Since I have had at least one person (actually, more than a couple) ask “Where is the Brewery?”, I have created a Google map. It doesn’t seem to be working at the moment, but hopefully it’ll fix itself. I can’t get stressed about it.

Don’t be fooled: the building still has the “Wild Goose” logo on the side and it isn’t that blinding Yellow & Blue that was the original Frederick Brewing Company’s colors. In case the map doesn’t self-correct, the brewery is on Wedgwood Blvd, between Buckeystown Pike (Rt 85), New Design Road and English Muffin Way. Yes, this is where Thomas’ English Muffins come from. I am assuming since you didn’t know the Brewery was there, you have never flipped over the box of Thomas’ English Muffins to see that they were made here in Frederick, either.

Maybe the next BioBeers will be at Thomas’, assuming we can BYOB and they’ll provide the muffins!?

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Akonni gets some help

Posted by Jim H on April 4, 2008

Rumor has it that Akonni has been awarded $200K by DBED to help expand their operations in Frederick. I like it! Maybe they’ll come to BioBeers?

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Seminars at the Fort this month

Posted by Jim H on March 9, 2008

I almost forgot to post the Seminar Series at Ft Detrick this month. There isn’t a lot on this list for me, but perhaps some of you may be interested. This series is open to the public, although primarily attended by people at NCI.

Bring a passport or other Fed Gov issued photo ID (your Md Drivers license will do) if you plan to get past the guards armed with M16’s at the gate without a cavity search

Monday, March 10, 2008
2:00:00 PM Dr. Jackie Bromberg Bldg 549 Auditorium
Jak/Stat3 Signaling and Tumorigenesis Details Series
Tuesday, March 11, 2008
8:00:00 AM Carl Wu, PhD Bldg 549 Conf. Rm B
Chromatin Architecture of Chromosome Centromere in Budding Yeast Details Series

10:00:00 AM Dennis Drayna Bldg 549 Auditorium
Strategies for Disease Gene Identification Details Series

1:30:00 PM Bldg 426 Conf. Rm
X-ray Crystal Structure of Scytovirin: A Lectin with Antiviral Activity Speaker: Tinoush Moulaei, MCL Targeted Mutations of Bovine alph 1, 3 galactosyltransferase (a1,, 3 FalT) that change its Sugar Donor Specificity: Applications in Nanobiology Speaker: Marta Pasek, CCR, Nanobiology Program Details Series

2:00:00 PM Bldg 549 Conf. Rm A
POSTER TITLE: The Molecular Structure of the Interface of the DA Receptor Containing Heteromers-AUTHORS: Shelley N. Jackson and Amina S Woods, NIDA, NIH SEMINAR TITLE: Modeling of PNA-DNA Non-Covalent Complexes-SPEAKER: Alice Delvolve, NIDA, NIH Details Series
Wednesday, March 12, 2008
12:00:00 PM Grace Yeh Bldg 549 Auditorium
Modulation of Carcinogen Activation and Detoxification by Novel NO-and Dithiolethione-NSAIDs Details Series

3:30:00 PM Dr. Tim Harkins Bldg 549 Auditorium
Whole Genome Sequencing to Somatic Mutation Detection: Recent Scientific Breakthroughs using the Genome Sequencer FLX Details Series

3:30:00 PM Dr. Tim Harkins Bldg 549 Auditorium
Whole Genome Sequencing to Somatic mutation Detection: Recent Scientific Breakthroughs using the Genome Sequencer FLX Details Series
Friday, March 14, 2008
10:00:00 AM Dr. Kenan Murphpy Bldg 539 Library
The lambda Red Recombination System - Mutational and Biochemical Analyses Details

12:00:00 PM Dr. Gene Shearer Bldg 549 Auditorium
HIV-1 Immunopathogenesis: Hijacking Immune Regulatory Mechanisms Details Series
Tuesday, March 18, 2008
8:00:00 AM Stephen J. Elledge, PhD Bldg 549 Conf. Rm B
Adventures in Mammalian Genetics Details Series

10:00:00 AM Lynn Jorde Bldg 549 Auditorium
Introduction to Population Genetics Details Series
Wednesday, March 19, 2008
12:00:00 PM Ana Gamero Bldg 549 Auditorium
Understanding the Role of STAT2 in Apoptosis, Cancer, and Inflammation Details Series
Friday, March 21, 2008
12:00:00 PM Dr. Stephan R. Targan Bldg 426 Conf. Rm
Central Role for TL1A (TNSF15)in Chronic Mucosal Inflammation: A New Target for Treatment of Crohn’s Disease Details Series

3:00:00 PM Terry R. Magnuson, PhD Bldg 549 Auditorium
X Inactivation: Existing Without Xist Details Series
Tuesday, March 25, 2008
8:00:00 AM Francis S. Collins, MD, PhD Bldg 549 Conf. Rm B
The Cancer Genome Atlas Project Details Series

10:00:00 AM Elaine Ostrander Bldg 549 Auditorium
Linkage Analysis and Complex Traits Details Series
Wednesday, March 26, 2008
9:00:00 AM Robert Fisher Bldg 549 Auditorium
SPR Arrays are Here to Stay Details Series

12:00:00 PM Art Friedlander Bldg 549 Auditorium
The Yin and Yang of the Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics Details Series

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The Double Edged Sword

Posted by Jim H on March 4, 2008

I read with interest the recent press release from Invitrogen that they have established a “Philanthropic Foundation.” I can’t restrain myself any longer. And let me be up front that this is a rant for my own benefit. I am stating facts as I know them and don’t have any specific documentation to back any of this up.

Invitrogen acquired Life Technologies (LTI) in 2000 after a 2-3 year struggle for control of LTI Board by the Dexter Corporation, that majority owners of LTI. For many years, the State of Wisconsin Teachers pension Fund (or it may have been WARF) was a 25 something percent owner of LTI stock, Dexter owned about 70 % and most of the remaining 5% was split between members of the Board of Dexter and the Executive Officers of LTI.

When I started in the old Molecular Diagnostics Division of LTI (now known as Digene) in 1988, sales of Maryland Produced products were about $20MM annually on overall sales of about $110MM (GIBCO products accounting for 90MM, primarily FBS products). Back in those days, Fetal was king, and because this was traded as a commodity, it was a wild ride. My recollection is that somewhere in the neighborhood of 40% of our revenue in those days was linked to Fetal Bovine Serum and derivatives.

So the timing for the explosion of Molecular Biology techniques couldn’t have been more perfect, because we needed some new products to offset the turbulent Fetal market.   LTI had already recruited some of the top molecular biology talent of the time. Hiring guys who were the first to isolate restriction endonucleases, Reverse Transcriptases, Cationic lipids, tranferases, polymerases, and competent cells. We were on the leading edge, creating tools for cloning and gene manipulation that were so advanced we had to explain to our customers how they could use them in their research.

Maryland produced products grew from about $20MM in 1988 to about $250MM by 2000 with gross margins approaching 80% in some cases.   The corporation was generating between $60MM and $80MM in cash year over year, most of which was paid as “special dividends” to the share holders (namely, Dexter, who were losing their shirts in their other businesses and were being raped by the EPA for years of pollution of the Boston Harbor). We built a new Corporate HQ in 1993 on Shady Grove (which was subsequently purchased and bungled by HGS) for $75MM, paid in cash and opened a new Manufacturing & distribution center in Frederick in 1994.

Somewhere in 1997 or 1998, Dexter announced that, due to the overwhelming success of LTI, they were going to sell off their other, less profitable divisions and focus on being a Life Sciences company. Shortly thereafter, International Specialty Products made an offer to the Wisconsin group for their 30% share of LTI that they could not refuse.

This little bit in Wikipedia is a good summary of things:

“Until 2000, Windsor Locks was home to the oldest corporation listed on the New York Stock Exchange, The Dexter Corporation. Established in 1767 as C.H. Dexter and Sons, the company grew from a family-owned saw and grist mill and evolved into a multi-national producer of long fiber papers and chemical laminates. In its 233 years of operation, the company grew from manufacturing tissues, toilet paper, and tea bags to marketing more specialized products like medical garments and industrial finishes. Faced with a proposed buyout by International Specialty Products Incorporated in 2000, the Dexter Corporation separated its three divisions and sold them off to avoid a hostile takeover. The Life Sciences division merged with Invitrogen Corporation. The Specialty Polymers division was sold in part to Akzo Nobel, and the remaining businesses merged with Loctite Corporation. The third division, Dexter Nonwoven Materials, located on the company’s original site in Windsor Locks, was sold to the Finnish Ahlstrom Paper Group. The physical plant was expected to continue operating, but the corporate headquarters were closed. “

This is not entirely accurate: Invitrogen purchased Dexter for $1.9BB. Part of the purchase agreement was that Dexter had arranged buyers for the other divisions, but technically Invitrogen sold off the other divisions.

But anyway, Invitrogen came in and immediately began making plans to purchase all of the land available in the Omega Center in Frederick in order to relocate R&D and all of the Carlsbad operations to Frederick. After all, Invitrogen, prior to purchasing NOVEX about 6 months before, was only a 20-30MM/yr business and they were buying up the leader in the industry, with about 1,200 full time employees in Maryland: 800 or so at “The Palace” HQ in Gaithersburg and 400 in Frederick.

After we’d made arrangements to purchase the Omega Center, suddenly communications with the new owners stopped. A couple weeks goes by and something is obviously wrong. Plans have changed and we weren’t in on the decision. Not a good sign. Then word comes out that everything is moving to Carlsbad and Maryland Operations are to be terminated.

Everything in Maryland is slashed, aside from 30 or so people Custom Primers, facilities and IT in Frederick between 2000 and 2002.  800 or so in a single day just after Thanksgiving 2000, yours truly included.

Why the change in plans? As it turns out, the CEO at the time’s wife was from Hagerstown and fancied a move back east. Long story short, CEO gets caught with his pants down while running back and forth to Maryland, wife drops CEO, wife gets half his money, everyone in Maryland loses their job.

And all of this because we were so successful.

I am glad to see that Invitrogen decided to can the CEO in question and hire a bunch of guys from GE, the Jack Welsh types, to turn things around. They’ve resumed operations in Maryland, firing the Distribution center up again (one of their biggest strategical errors was shutting it down in the first place.  That must have cost them millions) and even getting the fermentation suites back up and running. They are pushing Six Sigma and Lean as a way of life. Funny thing is, I was pushing this agenda from 1995 to 200, but was told in 2000 by Invitrogen they have no interest in this philosophy. I was, yet again, ahead of the times.

So maybe now they have embraced the philosophy that people matter.  Maybe now they can try to rebuild the great enterprise we all worked for years to establish that was Life Technologies.  The company voted as one of the top 10 places to work in the country, where we had community outreach programs, lactation suites for new mothers, generous bonus and paid time off structure.  But more importantly, for the most part the people cared. They wanted to do the right thing.  They were being treated well and treated the company well in return.  This is not to say that we didn’t have our share of scandal, trysts, dishonest managers, lazy workers, sexual harassment and racial discrimination law suits.  We certainly did.  But in spite of it all we were incredibly successful and made a lot of people a lot of money and advanced the concept of molecular biology as common practice.

As I alluded to in an earlier post, the disintegration of LTI-Maryland have proved to be a boom for growth in Biotech in the region, as the people with talent (who flocked out if they were not forced out) seeded other companies in the region or started their own companies.

OK, I am done. I’m glad I got that out.

Posted in News, Rants, Rumors, Uncategorized | 2 Comments »

NCI Seeks Collaborators

Posted by Jim H on October 26, 2007

Saw this tonight, thought others may be interested

NEW YORK (GenomeWeb News) — The National Cancer Institute is looking to license or co-develop a microRNA sequence that it said can enhance the capacity of T-lymphocytes to recognize tumors in several kinds of cancer, according to the National Institutes of Health.

NIH said the technology, listed under patent application No. 60/940,172, is the “first reported use” of an miRNA gene to treat disease.

According to the agency, NCI discovered that genetically engineering T-lymphocytes with the gene, called miR-181a, “dramatically augmented the function of poorly responsive human tumor-infiltrating lymphocytes and TCR-engineered peripheral blood lymphocytes, resulting in potent anti-tumor reactivity.”

It also said that in a mouse model, miR-181a, “increased the function of self/tumor-specific CD8+ T cells enabling effective tumor destruction in the absence of vaccination or exogenous cytokines that were otherwise essential requirements.”

Pre-clinical work on miR-181a has been completed and clinical studies are being planned, the NIH said.

The IP is up for exclusive or non-exclusive license, NCI said.

NCI also said that its Surgery Branch seeks statements of interest from parties that want to “develop, evaluate, or commercialize the therapeutic use of microRNA-181a in the adoptive immunotherapy of cancer.”

Posted in Government Funded research, News, Rumors, Uncategorized | No Comments »